5-Amino-1MQ

Overview
5-Amino-1MQ is a small-molecule inhibitor commonly used to study NNMT (nicotinamide N-methyltransferase)—an enzyme that links methyl-donor use (SAM/SAH cycle) with NAD⁺ salvage and cellular energy programs. We keep things straightforward: clean labeling, clarity-first specs, and access to batch documentation so you can verify exactly what you’re working with.

Key research highlights (in plain terms)

• Targeted enzyme inhibition — used to selectively inhibit NNMT, helping researchers map how cells handle methylation balance and NAD⁺ availability under controlled conditions.

• Metabolism readouts — applied in models tracking NAD⁺/NADH ratios, 1-methylnicotinamide (MNA) levels, and downstream signals (e.g., sirtuin/PARP-related panels) to connect enzyme activity with measurable outcomes.

• Cell & tissue models — suitable for adipocyte, hepatocyte, and myocyte systems examining energy use, lipid handling, and transcriptional responses to pathway modulation.

• Dose–response & selectivity — supports clear concentration–effect curves, off-target screening, and time-course studies for robust assay design.

• Comparative assays — useful alongside other NAD⁺-pathway modulators to differentiate mechanism, potency, and pathway bias in standardized setups.

Why Pegasus

• Purity you can verify: batch testing with documentation (COA available)

• Clarity in every vial: straightforward specs and labeling

• Consistency you can trust: stable sourcing and careful handling

Specifications

• Type: Small-molecule NNMT inhibitor (research grade)

• Form: Lyophilized/crystalline powder

• Appearance: White to off-white

• Purity: ≥98% (HPLC)

• Solubility: DMSO (preferred stock solvent); dilute into appropriate aqueous buffer per protocol

• Packaging: Labeled container with lot and batch ID

Storage & handling

• Store dry at −20 °C, protected from light and moisture

• Prepare concentrated stocks (e.g., in DMSO), aliquot, and store at −20 °C; avoid repeated freeze–thaw cycles

Included with your order

• Labeled container of 5-Amino-1MQ (research grade)

• Batch/lot ID with access to testing details (COA)